Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 31 Researches
8.2
USERS' SCORE
Medium or Average
Based on 3 Reviews
6.6
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
8
Our analysis focused on evaluating the cholesterol-lowering capabilities of Lactobacillus acidophilus strain AM13-1, isolated from a healthy individual.
We observed that this strain demonstrated a significant ability to remove cholesterol with a remarkable efficiency rate of 70%.
Additionally, the genome of AM13-1 revealed beneficial characteristics, including a lack of harmful factors and several probiotic-related genes.
However, our findings indicate that while the strain shows promise, more in-depth research is necessary to establish its practical benefits in everyday health.
We observed that this strain demonstrated a significant ability to remove cholesterol with a remarkable efficiency rate of 70%.
Additionally, the genome of AM13-1 revealed beneficial characteristics, including a lack of harmful factors and several probiotic-related genes.
However, our findings indicate that while the strain shows promise, more in-depth research is necessary to establish its practical benefits in everyday health.
Read More
9
We explored the effectiveness of the probiotic strain CCFM1376 in managing high cholesterol in mice. Through a controlled study, mice were fed a high-cholesterol diet alongside CCFM1376 for eight weeks.
Results showed that CCFM1376 led to lower total and LDL cholesterol levels, while boosting HDL cholesterol. The strain also increased the presence of beneficial bile acids in the body. These findings suggest that CCFM1376 may be a promising probiotic approach for improving cholesterol levels.
Results showed that CCFM1376 led to lower total and LDL cholesterol levels, while boosting HDL cholesterol. The strain also increased the presence of beneficial bile acids in the body. These findings suggest that CCFM1376 may be a promising probiotic approach for improving cholesterol levels.
Read More
9
Lactobacillus postbiotics reduce cholesterol
We examined how postbiotics from Lactobacillus species could help lower cholesterol levels. Using both in vitro and in vivo studies, we found that yogurt fortified with these postbiotics led to notable reductions in total cholesterol, triglycerides, and LDL levels in Wistar rats on a high-cholesterol diet.
Not only did the yogurt show significant antioxidant and antibacterial benefits, but these results also indicate that such functional foods could be a meaningful approach for managing cholesterol and protecting against foodborne pathogens.
Not only did the yogurt show significant antioxidant and antibacterial benefits, but these results also indicate that such functional foods could be a meaningful approach for managing cholesterol and protecting against foodborne pathogens.
Read More
Most Useful Reviews
0
Negative experience
24 people found this helpful
I initially had high hopes for this drug due to positive reviews. Unfortunately, it caused me constant bloating and stabbing pain in my liver after a week. I followed the instructions diligently, but the discomfort persisted daily until I ceased taking the probiotics. Immediately, my swelling and pain subsided. I won't be trying these again, as previous probiotics had worked wonderfully for me.
Read More
0
No effect
1 people found this helpful
A paleo enthusiast recommended this probiotic, claiming it's high-quality. However, it didn't seem to work for me, and I experienced a lack of bowel movements and bloating after switching from California Gold 30 billion. Are the ingredients genuinely effective?
Read More
2
No positive effects
1 people found this helpful
I did not experience any positive effects from Jarrow Formulas Jarro-Dophilus EPS. It failed to alleviate my constipation. I will revert to Yakult probiotics drink. Moreover, the pills arrived warm, potentially affecting their efficacy, and they had an unpleasant rubbery smell. Additionally, I encountered dry skin and minor acne after using it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 31 Researches
8.2
- All Researches
9
We explored the effectiveness of the probiotic strain CCFM1376 in managing high cholesterol in mice. Through a controlled study, mice were fed a high-cholesterol diet alongside CCFM1376 for eight weeks.
Results showed that CCFM1376 led to lower total and LDL cholesterol levels, while boosting HDL cholesterol. The strain also increased the presence of beneficial bile acids in the body. These findings suggest that CCFM1376 may be a promising probiotic approach for improving cholesterol levels.
Results showed that CCFM1376 led to lower total and LDL cholesterol levels, while boosting HDL cholesterol. The strain also increased the presence of beneficial bile acids in the body. These findings suggest that CCFM1376 may be a promising probiotic approach for improving cholesterol levels.
Read More
9
Lactobacillus postbiotics reduce cholesterol
We examined how postbiotics from Lactobacillus species could help lower cholesterol levels. Using both in vitro and in vivo studies, we found that yogurt fortified with these postbiotics led to notable reductions in total cholesterol, triglycerides, and LDL levels in Wistar rats on a high-cholesterol diet.
Not only did the yogurt show significant antioxidant and antibacterial benefits, but these results also indicate that such functional foods could be a meaningful approach for managing cholesterol and protecting against foodborne pathogens.
Not only did the yogurt show significant antioxidant and antibacterial benefits, but these results also indicate that such functional foods could be a meaningful approach for managing cholesterol and protecting against foodborne pathogens.
Read More
9
We investigated how Lactobacillus ATCC8014 affects high cholesterol in postmenopausal mice. By feeding female mice a high-fat diet and administering Lactobacillus for 13 weeks, we saw a significant reduction in total cholesterol and triglycerides.
This improvement was linked to increased excretion of secondary bile acids, which in turn helps to convert cholesterol. Our study suggests that Lactobacillus may offer therapeutic benefits for managing cholesterol levels in postmenopausal women through changes in gut bacteria and bile acid metabolism.
This improvement was linked to increased excretion of secondary bile acids, which in turn helps to convert cholesterol. Our study suggests that Lactobacillus may offer therapeutic benefits for managing cholesterol levels in postmenopausal women through changes in gut bacteria and bile acid metabolism.
Read More
9
We focused on how microencapsulating Lactobacillus plantarum LAB12 could help maintain its cholesterol-lowering benefits. By using a combination of alginate and pea protein, we created a protective environment for the probiotics.
This method not only improved the survival of LAB12 under harsh conditions but also showed promising results in lowering serum triglycerides and increasing HDL cholesterol in zebrafish with high cholesterol diets.
Overall, our findings suggest that microencapsulation could enhance the effectiveness of this probiotic in promoting heart health.
This method not only improved the survival of LAB12 under harsh conditions but also showed promising results in lowering serum triglycerides and increasing HDL cholesterol in zebrafish with high cholesterol diets.
Overall, our findings suggest that microencapsulation could enhance the effectiveness of this probiotic in promoting heart health.
Read More
9
We evaluated how Lactobacillus NCIMB (LRC™) affects high cholesterol by testing it on rats and liver cells.
Our research discovered that LRC can lower cholesterol levels by hampering the production of cholesterol in cells and enhancing cholesterol excretion through the intestines.
Notably, LRC effectively inhibited important enzymes and improved cholesterol transport. In essence, it appears that leveraging LRC could be a promising way to help manage cholesterol levels effectively.
Our research discovered that LRC can lower cholesterol levels by hampering the production of cholesterol in cells and enhancing cholesterol excretion through the intestines.
Notably, LRC effectively inhibited important enzymes and improved cholesterol transport. In essence, it appears that leveraging LRC could be a promising way to help manage cholesterol levels effectively.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 3 Reviews
6.6
- All Reviews
- Positive Reviews
- Negative Reviews
0
Negative experience
24 people found this helpful
I initially had high hopes for this drug due to positive reviews. Unfortunately, it caused me constant bloating and stabbing pain in my liver after a week. I followed the instructions diligently, but the discomfort persisted daily until I ceased taking the probiotics. Immediately, my swelling and pain subsided. I won't be trying these again, as previous probiotics had worked wonderfully for me.
Read More
0
No effect
1 people found this helpful
A paleo enthusiast recommended this probiotic, claiming it's high-quality. However, it didn't seem to work for me, and I experienced a lack of bowel movements and bloating after switching from California Gold 30 billion. Are the ingredients genuinely effective?
Read More
2
No positive effects
1 people found this helpful
I did not experience any positive effects from Jarrow Formulas Jarro-Dophilus EPS. It failed to alleviate my constipation. I will revert to Yakult probiotics drink. Moreover, the pills arrived warm, potentially affecting their efficacy, and they had an unpleasant rubbery smell. Additionally, I encountered dry skin and minor acne after using it.
Read More
Frequently Asked Questions
8
Probiotics reduce LDL cholesterol
We evaluated how a specific probiotic, TISTR 2593, affects cholesterol levels in patients with high cholesterol. Our randomized, double-blind, placebo-controlled trial involved 22 participants who took either the probiotic or a placebo daily for 90 days.
After the study, we observed important changes in the gut microbiome and a significant reduction in low-density lipoprotein (LDL) cholesterol in those taking the probiotic. These results suggest that TISTR 2593 might play a beneficial role in improving metabolic health and warrant further investigation into its long-term effects.
After the study, we observed important changes in the gut microbiome and a significant reduction in low-density lipoprotein (LDL) cholesterol in those taking the probiotic. These results suggest that TISTR 2593 might play a beneficial role in improving metabolic health and warrant further investigation into its long-term effects.
9
We explored how Lactobacillus rhamnosus BFE5264 affects cholesterol levels using a mouse model on a high-cholesterol diet. This study revealed that this strain significantly reduced serum cholesterol levels while also altering the gut microbiome and increasing beneficial short-chain fatty acids. The findings suggest that L. rhamnosus could regulate cholesterol metabolism in the liver, showing effects similar to those of statin medications. These results highlight the potential of probiotics as a novel approach for managing cholesterol levels.
8
We explored a promising approach to managing high cholesterol using a novel synbiotic made from Lactobacillus rhamnosus and xylo-oligosaccharides. This study simulated cholesterol-lowering effects and showed that this combination could regulate fat metabolism by affecting specific genes involved in cholesterol absorption.
While there is potential for these synbiotics to support cholesterol management, our findings serve primarily as a theoretical foundation for future products, rather than providing a definitive solution. Thus, more research is necessary to confirm these benefits in real-world applications.
While there is potential for these synbiotics to support cholesterol management, our findings serve primarily as a theoretical foundation for future products, rather than providing a definitive solution. Thus, more research is necessary to confirm these benefits in real-world applications.
References
- Chen K, Dang D, Li H, Ross RP, Stanton C, et al. CCFM1376 improves hypercholesterolemia in mice by regulating the composition of bile acids. Microbiome Res Rep. 2025;4:6. doi:10.20517/mrr.2024.38
- Chen Y, Zheng K, Leng Y, Zhang Z, Li X, et al. Alleviating effect of E15 on hyperlipidemia and hepatic lipid metabolism in zebrafish fed by a high-fat diet through the production of short-chain fatty acids. Front Nutr. 2025;12:1522982. doi:10.3389/fnut.2025.1522982
- Akbal S, Uğur Geçer E, Ertürkmen P. Probiotic Viability and Bioactive Properties of Buffalo Yoghurt Produced Using High Cholesterol-Assimilating Probiotic Strains. Vet Med Sci. 2025;11:e70233. doi:10.1002/vms3.70233
- Davarzani S, Sanjabi MR, Mojgani N, Mirdamadi S, Soltani M. Investigating the Antibacterial, Antioxidant, and Cholesterol-lowering Properties of Yogurt Fortified with Postbiotic of Lactobacillus acidophilus and Lactiplantibacillus plantarum in the Wistar Rat Model. J Food Prot. 2024;87:100408. doi:10.1016/j.jfp.2024.100408
- Dang L, Li D, Mu Q, Zhang N, Li C, et al. Youth-derived Lactobacillus rhamnosus with prebiotic xylo-oligosaccharide exhibits anti-hyperlipidemic effects as a novel synbiotic. Food Res Int. 2024;195:114976. doi:10.1016/j.foodres.2024.114976
- Nuankham K, Sitdhipol J, Chonpathompikunlert P, Khongrum J, Kittichaiworakul R, et al. Impact of () sup. TISTR 2593 Probiotic Supplementation on the Gut Microbiome of Hypercholesterolemia Patients: A Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16172916
- Zhang S, Liu R, Ma Y, Ma Y, Feng H, et al. ATCC8014 Alleviates Postmenopausal Hypercholesterolemia in Mice by Remodeling Intestinal Microbiota to Increase Secondary Bile Acid Excretion. J Agric Food Chem. 2024;72:6236. doi:10.1021/acs.jafc.3c08232
- Liu X, Wang M, Hu T, Lin X, Liang H, et al. Safety assessment of potential probiotic Lactobacillus acidophilus AM13-1 with high cholesterol-lowering capability isolated from human gut. Lett Appl Microbiol. 2024;77. doi:10.1093/lambio/ovad143
- Ismail MF, Lim SM, Lim FT, Ramasamy K. In Vitro and In Vivo Characterisation of Lactiplantibacillus plantarum LAB12 in Pea Protein-Alginate Microcapsules. Probiotics Antimicrob Proteins. 2025;17:569. doi:10.1007/s12602-023-10171-6
- Lee M, Park J, Kim OK, Kim D, Han MJ, et al. NCIMB 30242 (LRC) Inhibits Cholesterol Synthesis and Stimulates Cholesterol Excretion in Animal and Cell Models. J Med Food. 2023;26:529. doi:10.1089/jmf.2022.K.0137
- Pires V, Ribeiro SC, Silva SPM, Juraskova D, Silva CCG. Probiotic, technological, and health-related characteristics of lactobacilli isolated from breast milk. J Appl Microbiol. 2023;134. doi:10.1093/jambio/lxad122
- Zhao K, Qiu L, He Y, Tao X, Zhang Z, et al. Alleviation Syndrome of High-Cholesterol-Diet-Induced Hypercholesterolemia in Mice by Intervention with WLPL21 via Regulation of Cholesterol Metabolism and Transportation as Well as Gut Microbiota. Nutrients. 2023;15. doi:10.3390/nu15112600
- Lacroix S, Leblanc N, Abolghasemi A, Paris-Robidas S, Martin C, et al. Probiotic interventions promote metabolic health in high fat-fed hamsters in association with gut microbiota and endocannabinoidome alterations. Benef Microbes. 2023;14:223. doi:10.3920/BM2022.0080
- Aziz M, Hemeda SA, Albadrani GM, Fadl SE, Elgendey F. Ameliorating effect of probiotic on nonalcoholic fatty liver disease and lipolytic gene expression in rabbits. Sci Rep. 2023;13:6312. doi:10.1038/s41598-023-32584-7
- Khongrum J, Yingthongchai P, Boonyapranai K, Wongtanasarasin W, Aobchecy P, et al. Safety and Effects of TISTR 2593 Supplementation on Improving Cholesterol Metabolism and Atherosclerosis-Related Parameters in Subjects with Hypercholesterolemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2023;15. doi:10.3390/nu15030661
- Çiftci G, Çiftci A, Onuk B, Çenesiz M, Savaşan S, et al. Investigation of the effects of atorvastatin and Lactobacillus acidophilus on some hormones and oxidative stress in experimental hypercholesterolemia. Prostaglandins Other Lipid Mediat. 2023;165:106716. doi:10.1016/j.prostaglandins.2023.106716
- Correia Gomes D, Meza Alvarado JE, Zamora Briseño JA, Cano Sarmiento C, Camacho Morales A, et al. Maternal Supplementation with GG Improves Glucose Tolerance and Modulates the Intestinal Microbiota of Offspring. Diseases. 2024;12. doi:10.3390/diseases12120312
- Papakonstantinou E, Zacharodimos N, Georgiopoulos G, Athanasaki C, Bothou DL, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024;16. doi:10.3390/nu16091331
- Negm El-Dein A, Ezzat A, Aly HF, Awad G, Farid M. Lactobacillus-fermented yogurt exerts hypoglycemic, hypocholesterolemic, and anti-inflammatory activities in STZ-induced diabetic Wistar rats. Nutr Res. 2022;108:22. doi:10.1016/j.nutres.2022.10.003
- Zafar H, Ain NU, Alshammari A, Alghamdi S, Raja H, et al. FM9 and Y57 Are as Effective as Statins at Improving Blood Lipid Profile in High Cholesterol, High-Fat Diet Model in Male Wistar Rats. Nutrients. 2022;14. doi:10.3390/nu14081654
- Yoon H, Lee Y, Kang HJ, Ju J, Ji Y, et al. Two putative probiotic strains improve diet-induced hypercholesterolemia through modulating intestinal cholesterol uptake and hepatic cholesterol efflux. J Appl Microbiol. 2022;132:562. doi:10.1111/jam.15181
- Daliri EB, Kim Y, Do Y, Chelliah R, Oh DH. In Vitro and In Vivo Cholesterol Reducing Ability and Safety of Probiotic Candidates Isolated from Korean Fermented Soya Beans. Probiotics Antimicrob Proteins. 2022;14:87. doi:10.1007/s12602-021-09798-0
- Lee CS, Park MH, Kim BK, Kim SH. Antiobesity Effect of Novel Probiotic Strains in a Mouse Model of High-Fat Diet-Induced Obesity. Probiotics Antimicrob Proteins. 2021;13:1054. doi:10.1007/s12602-021-09752-0
- El-Dein AN, Nour El-Deen AM, El-Shatoury EH, Awad GA, Ibrahim MK, et al. Assessment of exopolysaccharides, bacteriocins and in vitro and in vivo hypocholesterolemic potential of some Egyptian Lactobacillus spp. Int J Biol Macromol. 2021;173:66. doi:10.1016/j.ijbiomac.2021.01.107
- Das S, Mishra BK, Hati S. Techno-functional characterization of indigenous isolates from the traditional fermented foods of Meghalaya, India. Curr Res Food Sci. 2020;3:9. doi:10.1016/j.crfs.2020.01.002
- Romão da Silva LF, de Oliveira Y, de Souza EL, de Luna Freire MO, Braga VA, et al. Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial. Food Funct. 2020;11:7152. doi:10.1039/d0fo01661f
- Wa Y, Yin B, He Y, Xi W, Huang Y, et al. Effects of Single Probiotic- and Combined Probiotic-Fermented Milk on Lipid Metabolism in Hyperlipidemic Rats. Front Microbiol. 2019;10:1312. doi:10.3389/fmicb.2019.01312
- Yan Y, Zhang F, Chai Z, Liu M, Battino M, et al. Mixed fermentation of blueberry pomace with L. rhamnosus GG and L. plantarum-1: Enhance the active ingredient, antioxidant activity and health-promoting benefits. Food Chem Toxicol. 2019;131:110541. doi:10.1016/j.fct.2019.05.049
- Park S, Kang J, Choi S, Park H, Hwang E, et al. Cholesterol-lowering effect of Lactobacillus rhamnosus BFE5264 and its influence on the gut microbiome and propionate level in a murine model. PLoS One. 2018;13:e0203150. doi:10.1371/journal.pone.0203150
- Oh NS, Joung JY, Lee JY, Kim Y. Probiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces. PLoS One. 2018;13:e0192021. doi:10.1371/journal.pone.0192021
- Roselli M, Devirgiliis C, Zinno P, Guantario B, Finamore A, et al. Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition. Genes Nutr. 2017;12:25. doi:10.1186/s12263-017-0583-1
